Download e-book for iPad: Animal models in cardiovascular research by David R. Gross DVM, PhD (auth.)

By David R. Gross DVM, PhD (auth.)

ISBN-10: 9401707308

ISBN-13: 9789401707305

ISBN-10: 9401707324

ISBN-13: 9789401707329

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0 mg/kg, mglkg, IV plus 20 min. rnin. 0 mglkg Pentobarbita I Significant decrease in cerebral blood flow, oxygen transport and consumption, renal blood flow and GI blood flow. When order of pentobarbital and fentanyl administration reversed magnitude of decrease was higher. 2 flglkg, flg/kg, 1M IM or IV Duration of approximately hour 1 2 Dose Cardiovascular Effects References Anesthetized with halothane and nitrous ha10thane oxide, open ehest, chest, acute preparation. Off halothane on 60-65% ha10thane nitrous oxide for 60 min rnin stabilization prior to dosing.

3 mglkg No cardiovascular data - some monkeys may require as much as 11 mg/kg. 3: Methadone Conditions of the Experiment Dose Cardiovascular Effects References Slight alterations in cardiovascular dynamics which whieh can be blocked by prior administration of atropine. Reduces required dose of barbiturate anesthesia by 1/2. 0 mglkg, IV mg/kg, Increased peripheral resistance. e. responses blocked by atropine. 3 mg/kg, IV No changes in heart rate, stroke volume, cardiac output, mean aortic pressures, me mean an pulmonary artery pressures, pulmonary artery wedge pressures, mean right atrial pressures, systemic resistance or pulmonary arterial resistance.

0 mg/kg, IV Induced an immediate but small increase in cardiac output, substantial increases in heart rate, mean systemic and pulmonary arterial pressures, left and right ventricular work, hematocrit and hemoglobin concentrations; no change in stroke volume or systemic vascular resistance 163 26 Chapter 2 Conditions of the Experiment Dose Cardiovascular Effects References Immediate increases in O2 consumption, CO2 production; hypermetabolic state persisted for approx. 1:8 Sheep Intact awake, pregnant ewes, previously instrumented 5 mg epidural No change in matemal maternal or fetal aortic blood pressure or acid-base status.

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Animal models in cardiovascular research by David R. Gross DVM, PhD (auth.)

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