By Mancia Giuseppe
Considering the fact that angiotensin II is likely one of the so much effective vasoconstrictors and a huge stimulus for the secretion of aldosterone from the adrenal gland, the advance of of angiotensin II inhibitors is a crucial step in regulating blood strain. This classification of drug is well-tolerated via pateints and those medications have the additional virtue over ACE inhibitors in that they're no longer linked to cough. simply because such a lot medicinal drugs might be given as soon as day-by-day and, like ACEIs, they've got an invaluable additive hypotensive impact together with diuretics, they're a welcome healing software within the remedy of high blood pressure. This moment version builds at the good fortune of the 1st and brings to the reader the entire most up-to-date advancements, scientific trial info, and the contributors's own views whilst treating sufferers with angiotensin II receptors antagonists.
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Extra info for Angiotensin II receptor antagonists : current perspectives
Owing to its long half-life of elimination (t ϭ 10–15 hours) once-daily administration appears to be suitable for blood pressure control for 24 hours. Its efficacy and safety are comparable with those of other AT1 blockers. Large-scale intervention studies such as OLMEBEST are ongoing. 556 26 7/3/06 4:05 pm Page 26 Comparative pharmacology Kinetic profile The maximal plasma concentration of olmesartan is achieved after 2 hours following oral ingestion. Bioavailability lies within the range of approximately 25%.
18. Kivlighn S, Zingaro GJ, Gabel RA et al. In vivo pharmacology of an angiotensin AT1-receptor antagonist with balanced affinity for angiotensin AT2-receptors. Eur J Pharmacol 1995; 294:439–50. 19. Wong PC, Quan ML, Saye JA et al. Pharmacology of XR 510, a potent orally active non-peptide angiotensin AT1-receptor antagonist with high affinity for the AT2-receptor subtype. J Cardiovasc Pharmacol 1995; 26:354–62. 20. Zhang J. Pharmacological effects of angiotensin II and non-peptidergic receptor antagonists.
Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. J Biol Chem 2004; 279:28989–97. 13. Seibold S, Rudroff C, Weber M et al. 3-22. FASEB J 2003; 17:1180–2. 14. Kaschina E, Unger T. Angiotensin AT1/AT2 receptors: regulation, signalling and function. Blood Press 2003; 12:70–88. 556 7/3/06 4:06 pm Page 43 References 43 15. Widdop RE, Jones ES, Hannan RE, Gaspari TA. Angiotensin AT2 receptors: cardiovascular hope or hype? Br J Pharmacol 2003; 140:809–24.
Angiotensin II receptor antagonists : current perspectives by Mancia Giuseppe